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Ellagic Acid

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What is Ellagic Acid? Well, scientifically speaking, Ellagic Acid is formed when polymers of gallic acid and hexahydroxydipenoyl (HHDP) are linked to glucose molecules to form compounds of ellagitannins. When two gallic acid groups become linked side by side within a tannin molecule, a HHDP group is formed. When the HHDP group is then bioactively separated from the tannin molecule, it spontaneously rearranges itself into subunits we call Ellagic Acid.

Ellagic acid is a type of phytochemical called a polyphenol, or plant cholesterol. It is released from the digestion of tannins contained in certain fruits and nuts. These water-soluble tannins are called ellagitannins, which have demonstrated anti carcinogenic and antimutagenic activity by inhibiting the multi-stage pathways. Ellagic acid is released from the ellagitannins during the digestive process. Several studies indicate that this ability occurs by:

1) Neutralizing carcinogens so that they cannot bind to the cellular DNA located in nucleus.
2) Activates the liver detoxification systems so that mutagens and carcinogens are quickly excreted.
3) Scavenges and expels dangerous highly reactive oxygen molecules free radicals.
4) Induces cells to undergo apoptosis or natural cell death.
5) Stimulates the immune system for the destruction of dangerous cells.

Ellagic acid has been found to promote healthy brain function and mental clarity, healthy vision, cardiovascular health, healthy skin, urinary tract health, and healthy blood sugar levels.

Ellagic Acid, can nourish, balance, protect, and provide the body with the building blocks necessary for growth, repair, vitality, and longevity.

Ellagic Acid is found in muscadine grapes

Dr. Nixon and other investigators and researchers, both in the United States and in Europe, found that daily consumption of Ellagic Acid may: Activate powerful detoxifying enzymes in the liver; This promotes the cleansing of the liver and the protection and regeneration of injured liver cells; Prevents the binding of carcinogens to the DNA of cells; Serves as a powerful antioxidant, which inhibits or destroys oxygen free radicals; May cause already established cells to undergo programmed normal cell death (apoptosis); Stimulates the immune system to destroy abnormal cells.

Dieticians have long stressed the importance of the consumption of fruits and vegetables for general health and well being, but now these food items are being recognized as even greater contributors to human health. Ellagic acid binds to DNA and acts as a shield, protecting DNA from mutagens and increases the expression of the enzyme p21, which arrests cell division of cells that have DNA damage.

Ellagic acid is a naturally occurring phenolic constituent in certain fruits and nuts. Ellagic acid found in muscadine grapes has proven to be an effective antimutagen and anticarcinogen as well. Antioxidants need to be given in forms that have a balanced REDOX potential and accessibility to body tissues. ELLAGIC ACID is a powerful antioxidant derived from muscadine grapes and has the ability to support cell structures.

  • Ellagic acid and elagitannins are powerful antioxidants from raspberries.
  • Ellagic acid has special effects on DNA replication and cell division.
  • Presented in a balanced manner with antioxidants of different REDOX value, with lipophilic and hydrophilic properties to access tissues of the body.
  • Ellagic acid has been found to occur naturally in 46 different foods, with the muscadine grape having been identified as having the highest ORAC

Research, which began many years ago, has concluded that ellagic acid, is a very powerful substance. One study showed that ellagic acid was able to induce the production of NAD(P)H:quinone reductase (QR), a major detoxification enzyme. Ellagic acid acts as a free radical scavenger to "bind" irritant-causing chemicals, making them inactive. It inhibits the ability of other chemicals to cause mutations in bacteria. Ellagic acid stimulates the activity of various isoforms of the enzyme glutathione-S-transferase that supports healthy cell growth.

Ellagic Acid - The Secret Agent in the Muscadine Grape
It is also believe that an extra pair of chromosomes is the reason that Muscadines contain Ellagic Acid.   Why is Ellagic Acid so important? There are numerous studies underway investigating the roll Ellagic Acid can play in cancer prevention. Ellagic Acid may aide in chemoprevention. Chemoprevention is a term that means to chemically prevent cancer from occurring, growing or metastasizing. There is great interest in chemoprevention (not to be confused with chemotherapy) because it may be the best way to fight cancer; stop it from growing before it reaches a level that causes problems.

Ellagic acid is a phenolic compound found in plants in the form of hydrolyzable tannins called ellagitannins. Ellagitannins are esters of glucose with hexahydroxydiphenic acid; when hydrolyzed, they yield Ellagic acid, the dilactone of hexahydroxydiphenic acid. Ellagic acid is a very stable compound and is readily absorbed through the gastrointestinal system in mammals, including humans.

Ellagic acid promotes carcinogen detoxification by stimulating the activity of various isoforms of the enzyme glutathione-S- transferase.

Ellagic acid has other beneficial effects on human health that take advantage of its separate but important anti-oxidant potential. Again, to understand this important function we must have a basic understanding of what anti-oxidants are and how they protect us.

The very act of breathing in oxygen creates within living systems very reactive and damaging molecules which are combinations of oxygen and hydrogen. These reactive species are catalyzed (produced) by certain metals that are located near our DNA molecules. These reactive species will seek to neutralize their imbalanced electrical by attempting to combine with nearby healthy molecules creating damage. Since the relative species are in close proximity to DNA molecules our genes can become a likely target resulting in DNA damage (mutations). It is known that ellagic acid can form adducts (gentle wrapping of our DNA molecules) with our genes and itself become a target for the reactive species and thus protecting the DNA. This protection of necessary molecules could be termed anti-oxidant potential.


Muscadine grapes prove not all SuperFruits need to come from exotic places. Think if you have seen one grape you have seen them all? You must have never seen the Muscadine grape!   Muscadine grapes grow in not so exotic places like - Georgia, North Carolina, South Carolina and Alabama. These are not the type of places we normally find SuperFruits - but the research does not lie, Muscadines are super!

What makes Muscadine grapes different?

Muscadines actually have an extra pair of chromosomes. Normal grapes have 19 pairs of chromosomes, while Muscadine grapes have 20 chromosomes. It is believed that this extra pair of chromosomes allows Muscadine grapes to products phytochemicals that are not found in any other grape. 
What Else Can Muscadine Help With? 
Muscadine is much more than just a great source of Ellagic Acid. Muscadine grapes have 6 times the resveratrol as red grapes. In addition, Muscadines have more antioxidants than red grapes and they are packed with phytonutrients. We could fill a book with details on the health benefits of the Muscadine grape - ut in short, it can help increase energy, regulate blood sugar, reduce free radicals, help the body build and repair and increase mental clarity.
How Come Muscadine Grapes Are Not More Popular? 

It is a sad secret of this industry, companies loves selling fruits from far away places with mythical stories. Supplement companies want to tell you a small tribe lives in some remote rain forest and eats Super Berry X and they all live to be 130 years old.

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Dietary supplements are not to be used to prevent or treat any disease. The Statements on this web page have not been evaluated by the FDA. Any information provided on this website is not a substitute for the advice of a licensed medical practitioner. Individuals are advised not to self-medicate in the presence of significant illness. Ingredients in supplements are not drugs and may not be foods.

Ziva with
ellagic acid inmuscadine grapesEllagic Acid can be found in Muscadine Grapes.  The product we recommend is called Ziva.  Please visit our online product store here
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