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Argireline:
Inhibits Wrinkle Formation
Argireline is a unique new peptide that both reduces the degree of
existing facial wrinkles and has been demonstrated effective against
their development. It’s been shown to inhibit the formation of the
SNARE complex as well as catecholamine release. These inhibitions
confer anti-aging activity on Argireline; they closely relate to the
basic biochemical mechanisms of wrinkle formation. Controlled
studies have also demonstrated that facial wrinkle depth can be
reduced, especially in the forehead and around the eyes, and that
Argireline can prevent apparent facial skin aging. Skin topographic
analysis performed on healthy female volunteers confirmed
the validation fo the proposed biochemical mechanism of action.
Causes of Facial Wrinkling
Facial wrinkling associated with aging is caused – and exacerbated – by
many factors. Beyond the physiological pathways, molecular mechanisms
involved in facial aging include changes in collagen conformation,
elastin polypeptide degradation, and problems of the skin’s lipid
matrix. Recent studies clearly establish that these changes can be
significantly reduced by inhibiting SNARE complex formation, a core of
membrane proteins that mediate neuronal exocytosis. Their
inhibition by short synthetic peptides can decrease facial wrinkle
formation, and thereby the appearance of aging. The
overproduction and release of cate-cholamines also encourages the
formation of wrinkles and fine lines.
The Technology
Argireline’s specific sequence was shown to inhibit
the SNARE complex formation and catecholamine release. Once identified,
it was synthesized by solid phase peptide synthesis and then purified
and characterized. Argireline solution was found to inhibit
vesicle docking by preventing formation of the essential ternary SNARE
Complex. Inhibition of noradrenaline and adrenaline release was also
demonstrated in a second in vitro study. In vivo tests further
demonstrated the benefits of Argireline solution. Facial topography
analysis (for measuring the effectiveness of an
O/W emulsion containing 10% Argireline solution) was performed using
silicon replicas from around the eyes at 0, 15 and 30 days of a
twice-a-day treatment regimen. Analyses of the imprints were performed
by confocal laser scanning microscopy. It was observed that the
severity of wrinkles around the eyes decreased up to 17% after 15 days
of treatment and up to 27% after 30 days of treatment,
substantiating the proposed biochemical mechanism hypothesis.
Hyaluronic Acid: A Powerful
Humectant
When the air is dry, your skin will lose moisture.
Regular moisturizers typically give about 30 minutes of topical
moisture...and they *feel* moisturizing for a brief period of time
until environmental elements dry the skin once again. Humectants
work by helping the skin retain natural moisture from the liquids you
drink and work as a "water-reservoir" for skin cells....they bind water
within the intercellular structure of the skin. When skin cells can't
get enough water from the reservoir, aging issues are more pronounced.
What is Hyaluronic Acid?
Hyaluronic acid is the most effective humectant available and is found
in most hospital burn units for the hydration of severely damaged skin.
With sufficient water intake (optimally 6-8 glasses of water each day)
Hyaluronic Acid Serum will add moisture to the skin, even in the driest
climates.....this product does not depend on atmospheric moisture.
Benefits
1. Deep hydration of skin cells.
2. "Plumps-up" skin tissue to soften wrinkles, lines.
3. Provides a smoother, silky texture to the skin.
4. Good for all skin types.
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Dietary supplements are not to be used to
prevent
or treat any disease.
The Statements on this web page have not been evaluated by the FDA. Any
information provided on this website is not a substitute for the advice
of a licensed medical practitioner. Individuals are advised not to
self-medicate in the presence of significant illness. Ingredients in
supplements are not drugs and may not be foods. |
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